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What's New

Explore recent and historical product updates for Revvity Signals' Cloud Native SaaS Software 

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What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. Basic chemical properties of structures and biopolymers can now be selected for addition to a drawing from the Analysis panel. Additionally, hydrogen bonded fragments are now recognized as a single structure. This release also includes several bug fixes, further improving the overall user experience.

The following improvements are available for users of Signals ChemDraw.

ChemDraw+

  • Enhanced property selection control when adding to drawings

  • Hydrogen-bonded fragments are treated as a single structure




     

ChemDraw+

Add selected chemical properties to the ChemDraw canvas

The Analysis panel now offers improved flexibility when adding chemical properties to drawings. Users can now choose which properties to add to their drawing when using the 'Add to Drawing' button located at the bottom of the Analysis panel. Selecting this button now opens a window where properties can be selected to be pasted onto the canvas.

Hydrogen-bonded fragments are treated as a single structure

Hydrogen bonded fragments in ChemDraw will now be recognized as a single structure with properties such as molecular weight, molecular formula and exact mass being calculated accordingly.


What’s New

The latest release of Signals brings significant improvements to the ChemDraw+ application. Users can now enjoy an enhanced drawing experience with the ability to customize structure appearances using 'Drawing Settings'. Additionally, a new 'Analysis' panel has been introduced, allowing users to analyze structures and biopolymers and obtain basic chemical properties based on their selection. The auto-pair tool has been expanded with new capabilities, and a new selection behavior provides clearer visualization of selections on the ChemDraw canvas. Export options within the application have also been expanded. This release also includes several bug fixes, further improving the overall user experience.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

  • Drawing settings are now customizable
  • Basic properties are now accessible in the Analysis panel
  • Auto-pair tool now accepts RNA/DNA strands with pendant Chem or peptide monomers 
  • Enhanced selection behavior for atoms, bonds and structures
  • Attach Data can now be added as chemically significant
  • Drawings can now be exported as molfile and SDfile (v3000)


     

ChemDraw+

Drawing Settings are now customizable

Users can now customize drawing settings in ChemDraw+, providing enhanced control to create drawings tailored to specific formatting needs. These settings are accessible from a new 'Drawing Settings' tool in the top right of the toolbar, which opens a dialog with tabbed sections that allow for customization of structure and HELM settings, as well as text and color settings. Each section contains a preview of a structure or biopolymer that reflects the current settings. When changes are made, the preview dynamically updates to display these changes. 

In the "Structure" tab, users can adjust various drawing settings to change how a structure looks on the canvas. They can modify bond lengths and widths, as well as chain angles. Users can also set other preferences to match their preferred drawing style, such as showing stereochemistry or atom numbers.  

In the 'HELM' tab, users can adjust various drawing settings that change how biopolymers are displayed on the canvas. These settings include the option to limit the number of residues per line and showing or hiding termini, bonds, unlinked branches, residue IDs and the 5' and 3' ends of oligonucleotides.

In the 'Text' tab, users can modify text properties such as font, text size and style to ensure text captions and atom labels are presented exactly as required.

In the 'Colors' tab, users can customize the foreground and background colors of the drawing, creating visually distinct drawings that align with their preferences and needs.

 

Basic chemical properties are now accessible in the Analysis panel

A new 'Analysis' panel in the ChemDraw editor now displays basic chemical properties for structures and biopolymers. These properties are context-sensitive, based on the selection on the canvas, and include information such as chemical name, molecular weight, molecular formula, and exact mass. Users can also add a selection of these properties directly to their drawing by using the 'Add to Drawing' button located at the bottom of the panel. 

Auto-pair tool now accepts RNA/DNA strands with pendant Chem or peptide monomers

The auto-pair tool has been improved to work with a wider range of RNA and DNA strands. This enhancement allows strands that include additional Chem or peptide monomers when finding the complementarity between strands and placing hydrogen bonds between them. 

Enhanced selection behavior for atoms, bonds and structures

There is now enhanced visualization in ChemDraw when atoms, bonds and structures are selected on the canvas. ChemDraw now individually highlights all the atoms, bonds and structures that are part of the selection, in addition to the selection box that appears upon selection on the canvas. This new behavior provides a clear distinction between selected and unselected elements on the canvas.

Attach Data can now be added as chemically significant

When annotating a molecule or stereocenter in ChemDraw using the 'Attach Data' capability, annotations can now be specified as 'chemically significant'. When this option is selected, annotations become chemically significant and are recognized and honored in chemical searches. Additionally, users can now edit existing annotations by selecting them and reopening the 'Attach Data' dialog in ChemDraw.

Drawings can now be exported as molfile and SDfile (v3000)

ChemDraw+ now offers more ways to export drawings. Users can now save their work as V3000 molfiles and sdfiles.


What’s New

ChemDraw version 25.0 introduces a range of enhancements designed to improve the drawing and representation of large molecules and complementary strands. This latest release also includes installation and system improvements, along with enhanced chemical intelligence updates. Finally, we have also fixed a number of small bugs.

The following updates are available as part of this release:

  • Advanced biopolymer (HELM) improvements - Improved visualization and clean-up of biopolymers
      - Curved connections between biopolymer sequences for improved visual clarity
      - Flexible line wrapping options for biopolymer display
      - Hydrogen bonds can be drawn between complementary DNA/RNA strands
      - Support for atom-mapped SMILES in HELM strings
      - HELM in-line annotation, sense/antisense annotations & 5’ and 3’ designations of RNA/DNA now supported
 

  • Enhanced chemical intelligence
     - Unified handling of coordination and dative bonds 
     - Updated stereochemistry labeling of allenes and atropisomers (R/S -> M/P)
 

  • Installation and system improvements
     - Streamlined installation with combined all user/current user options and improved installer behavior
     - ChemDraw is now available for ARM Macs and Intel Macs
     - Separate ChemDraw and ChemDraw Applications installers now provided
 

Advanced biopolymer (HELM) improvements

There have been significant improvements to how ChemDraw renders complex biopolymer sequences to provide a clear and concise representation of complex sequences. These improvements include updates to the visualization and routing of crosslinks between sequences, as well as clean structural visualizations for all monomers that may be expanded within a sequence.

Crosslinks between biopolymer sequences are also now curved, replacing the previous sharp-cornered design. This change significantly improves the visual clarity of complex structures, allowing users to easily distinguish between crosslinks and chemical linkages between monomers.

There are now enhanced options for the drawing and display of biopolymers in ChemDraw. In addition to being able to set the number of residues per line for biopolymers, a new feature is now available in the biopolymer document settings allows users to disable line wrapping of sequences entirely. When this setting is turned off, biopolymers will be drawn in a single, continuous line without any wrapping. Finally, the residues per block option has been removed from the biopolymer display settings.

Chemists can now manually draw hydrogen bonds between complimentary strands of DNA/RNA that are generated in ChemDraw containing non-natural nucleobases. The hydrogen bonding tool can be selected and used to place the appropriate hydrogen bonds according to Watson-Crick base pairing of the natural nucleobase analog.

Atom-mapped SMILES are now supported in ChemDraw when inserting HELM strings or pasting them to the canvas. Additionally, when generating a HELM string for a sequence that includes an unknown or in-line monomer, the resulting HELM string will now use atom-mapped SMILES. This replaces the previously used extended SMILES format.

Inline annotations of monomers and polymers as well as sense/antisense annotations and 5’/3’ designations are supported in ChemDraw and appear when present in a cdxml or are part of a pasted HELM string. They also now also persist to MOL files in SGROUPS.

Enhanced Chemical Intelligence

Stereocenters of allenes and atropisomers are now labelled with M and P (instead of the former R and S).

ChemDraw now treats coordination bonds and dative bonds identically, ensuring consistent valence calculations and stereochemical perception for these chemically equivalent bond types. Additionally, coordination and dative bonds match each other in searches, but do not match single bonds. 
 

The handling of the DISPLAY option in MOL files has been changed, as follows: 

  • The value of DISP is set to COORD by default if not present in the MOL file
  • DISP is always set to COORD for coordination bonds

Installation and System Improvements

The installation of ChemDraw has been streamlined with this release, containing combined all user/current user options and improved installer behavior. This update simplifies the installation process by merging user options and enhancing the overall behavior of the installer, making it more user-friendly and efficient. 

ChemDraw is now available for ARM Macs and Intel Macs. The type of installation is selected at run time depending on the machine architecture. 

Two separate installers are now available: one for ChemDraw and another for ChemDraw Applications. The ChemDraw Applications installer includes ChemDraw for Excel, Chem3D, ChemFinder, ChemScript, and ChemFinder for Office.


What’s New

The latest release of Signals introduces enhancements to the ChemDraw+ application. Specifically, coordination bonds are now treated identically to dative bonds in both chemical perception as well as chemical search. Additionally, improvements to visualization of biopolymers have been made. Finally, several bug fixes have been extended with this release.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

-    Coordination bonds are now identical to dative bonds
-    Show/hide residue IDs of biopolymers


 

ChemDraw+

Coordination bonds are now identical to dative bonds

ChemDraw now treats coordination bonds and dative bonds identically, ensuring consistent valence calculations and stereochemical perception for these chemically equivalent bond types. Additionally, these bonds will match each other when searching, meaning that structures containing a dative bond will match those containing a coordination bond in the same position and vice versa.  

Show/hide residue IDs of biopolymers

It is now possible to show and hide the residue IDs of biopolymers on the ChemDraw canvas. Upon selection of a biopolymer, the show/hide residue ID option checkbox will be available in the “Monomer” section of the Properties panel.


What’s New

The latest release of Signals introduces enhancements to the ChemDraw+ application.  Structure based searching capabilities have been added to allow users to filter and search for drawings containing chemical structures. Additionally new capabilities and enhancements have been made to the HELM drawing capabilities. Finally, several bug fixes have been extended with this release.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

-    Structure based searching
-    Sharing of Drawings
-    HELM in-line annotation support for monomers and polymers 
-    Biopolymer connections now appear curved instead of sharp corners


 

ChemDraw+

Structure based searching

New filtering and search capabilities have been added to the application for filtering and searching drawings based on chemical structures. Available as a button next to the text search field in the list views, the ‘Draw…’ button opens a structure editor. 

After drawing a structure, users can select from substructure, similarity, full, and exact search options. Selecting 'Search' will then initiate the search filter.  

After completing a structure search, the 'Draw' button transforms into an 'Edit' button. Selecting this button allows for previewing the structure, making changes to it, or removing it from the search filter. Structure searches can be combined with text-based searches to refine results even further.

Sharing of Drawings

Users can now share Drawings with other users or groups in ChemDraw+ from within a drawing or from the Actions menu in a Drawings list view.

During the sharing process, you can specify Read, Write, or Full access permissions. Once shared, these permissions can be modified or revoked as needed.
 



Recipients will receive an automatic notification when a drawing is shared with them.

HELM in-line annotation support for monomers and polymers

Annotation capabilities are now available for monomers and biopolymers through the properties panel. When a monomer or biopolymer is selected, users can access a new Annotation field in the Monomer or Biopolymer section, allowing them to add simple text and descriptions to specific parts of their sequence. For annotated monomers, a badge appears on the graphic to indicate the presence of an annotation which is also viewable in the hover-over preview. 

Biopolymer annotations are directly added to the ChemDraw canvas, appearing centered above or below the sequence. These annotations can be imported from HELM strings and are added as in-line annotations to the HELM string when generated. 

Biopolymer connections now appear curved instead of sharp corners

Biopolymer visualization has been refined in this release with the introduction of curved crosslinks and connections, replacing the previous sharp-cornered design. This enhancement significantly improves the visual clarity of complex structures, allowing users to easily distinguish between crosslinks and chemical linkages between monomers.


What’s New

The latest release of Signals introduces enhancements to the ChemDraw+ application.  Structure based searching capabilities have been added to allow users to filter and search for drawings containing chemical structures. Additionally new capabilities and enhancements have been made to the HELM drawing capabilities. Finally, several bug fixes have been extended with this release.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

-    Structure based searching
-    Sharing of Drawings
-    HELM in-line annotation support for monomers and polymers 
-    Biopolymer connections now appear curved instead of sharp corners


 

ChemDraw+

Structure based searching

New filtering and search capabilities have been added to the application for filtering and searching drawings based on chemical structures. Available as a button next to the text search field in the list views, the ‘Draw…’ button opens a structure editor. 

After drawing a structure, users can select from substructure, similarity, full, and exact search options. Selecting 'Search' will then initiate the search filter.  

After completing a structure search, the 'Draw' button transforms into an 'Edit' button. Selecting this button allows for previewing the structure, making changes to it, or removing it from the search filter. Structure searches can be combined with text-based searches to refine results even further.

Sharing of Drawings

Users can now share Drawings with other users or groups in ChemDraw+ from within a drawing or from the Actions menu in a Drawings list view.

During the sharing process, you can specify Read, Write, or Full access permissions. Once shared, these permissions can be modified or revoked as needed.
 



Recipients will receive an automatic notification when a drawing is shared with them.

HELM in-line annotation support for monomers and polymers

Annotation capabilities are now available for monomers and biopolymers through the properties panel. When a monomer or biopolymer is selected, users can access a new Annotation field in the Monomer or Biopolymer section, allowing them to add simple text and descriptions to specific parts of their sequence. For annotated monomers, a badge appears on the graphic to indicate the presence of an annotation which is also viewable in the hover-over preview. 

Biopolymer annotations are directly added to the ChemDraw canvas, appearing centered above or below the sequence. These annotations can be imported from HELM strings and are added as in-line annotations to the HELM string when generated. 

Biopolymer connections now appear curved instead of sharp corners

Biopolymer visualization has been refined in this release with the introduction of curved crosslinks and connections, replacing the previous sharp-cornered design. This enhancement significantly improves the visual clarity of complex structures, allowing users to easily distinguish between crosslinks and chemical linkages between monomers.


What’s New

The latest release of Signals introduces significant enhancements to the ChemDraw+ application.  HELM editing capabilities have been substantially expanded, now featuring the ability to create complementary strands with hydrogen bonding with several different new tools. We've improved the user drawing experience by incorporating a new drawing tool and access to symbols commonly used in chemical names and reactions. Finally, several bug fixes have been extended with this release. 

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

-    Selection of attachment points between monomers to create biopolymer crosslinks
-    Complementary strands generated from text tab now contain hydrogen bonds
-    Generate complementary strand tool 
-    HELM Auto-pair tool
-    Show 3' and 5' ends of oligonucleotides
-    Chemical Symbols
-    Join tool

 

ChemDraw+

Selection of attachment points between monomers to create biopolymer crosslinks 

The creation of biopolymer crosslinks between monomers with multiple possible attachment points is now supported. When creating a crosslink, the monomers will now expand, allowing users to select specific attachment points to make the connection. After making the selection, users can finalize the process by selecting "Connect," and the monomers will be successfully crosslinked. 

Complementary strands generated from text tab now contain hydrogen bonds

Complementary strands of RNA or DNA that are created from the text tab of the HELM editor are now created with hydrogen bonds automatically mapped between the strands. The hydrogen bonds are placed according to Watson-Crick base pairing. Hydrogen bond pairing information is also now supported in ChemDraw when inserting HELM strings or pasting them on the canvas. Additionally, when generating a HELM string for a sequence containing hydrogen bonds, the resulting HELM string will now contain the pairing details.

Generate complementary strand tool

Complementary strands of oligonucleotides can now be generated from a selected oligonucleotide on the ChemDraw canvas.  This new tool is available on the right-hand context toolbar allows users to generate a complementary strand when an oligonucleotide is selected. When this new tool is used, a complementary strand will be generated with hydrogen bonds automatically mapped between the strands. The hydrogen bonds are placed according to Watson-Crick base pairing. For sequences containing custom monomers, the complement will be based on the natural monomer equivalents of the selected sequence.

HELM Auto-pair tool

Complementary strands of oligonucleotides can now be selected and automatically paired in the new ChemDraw editor. When paired, hydrogen bonds will be placed between the strands according to Watson-Crick base pairing, with maximum overlap in complementarity between the strands. For sequences containing custom monomers, the hydrogen bonding will be placed according to Watson-Crick base pairings based on the natural monomer analogs. The auto-pair tool will appear on the right-hand context toolbar when two oligonucleotide sequences are selected.

Show 3' and 5' ends of oligonucleotides

A new option has been added to the Biopolymer section of the Properties panel in the new ChemDraw editor which allows users to display the 3' and 5' ends of an oligonucleotide on the canvas. When an oligonucleotide is selected, users can choose to show or hide the label by selecting or unselecting this option.

Chemical Symbols

Common symbols used in chemical names and reaction conditions can now be added to a ChemDraw text element in the new ChemDraw editor using the new Chemical Symbols tool. This tool will be available on the right-hand context toolbar when editing in a text element on the ChemDraw canvas.

Join tool

A new join tool is now available on the right-hand context toolbar of the new ChemDraw editor. When used, the join tool allows users to combine structures on the ChemDraw canvas by merging two or more selected atoms into a single atom.


What’s New

The latest release of Signals introduces significant enhancements to the ChemDraw+ application.  HELM editing capabilities have been substantially expanded, now featuring the ability to create complementary strands with hydrogen bonding with several different new tools. We've improved the user drawing experience by incorporating a new drawing tool and access to symbols commonly used in chemical names and reactions. Finally, several bug fixes have been extended with this release. 

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

-    Selection of attachment points between monomers to create biopolymer crosslinks
-    Complementary strands generated from text tab now contain hydrogen bonds
-    Generate complementary strand tool 
-    HELM Auto-pair tool
-    Show 3' and 5' ends of oligonucleotides
-    Chemical Symbols
-    Join tool

 

ChemDraw+

Selection of attachment points between monomers to create biopolymer crosslinks 

The creation of biopolymer crosslinks between monomers with multiple possible attachment points is now supported. When creating a crosslink, the monomers will now expand, allowing users to select specific attachment points to make the connection. After making the selection, users can finalize the process by selecting "Connect," and the monomers will be successfully crosslinked. 

Complementary strands generated from text tab now contain hydrogen bonds

Complementary strands of RNA or DNA that are created from the text tab of the HELM editor are now created with hydrogen bonds automatically mapped between the strands. The hydrogen bonds are placed according to Watson-Crick base pairing. Hydrogen bond pairing information is also now supported in ChemDraw when inserting HELM strings or pasting them on the canvas. Additionally, when generating a HELM string for a sequence containing hydrogen bonds, the resulting HELM string will now contain the pairing details.

Generate complementary strand tool

Complementary strands of oligonucleotides can now be generated from a selected oligonucleotide on the ChemDraw canvas.  This new tool is available on the right-hand context toolbar allows users to generate a complementary strand when an oligonucleotide is selected. When this new tool is used, a complementary strand will be generated with hydrogen bonds automatically mapped between the strands. The hydrogen bonds are placed according to Watson-Crick base pairing. For sequences containing custom monomers, the complement will be based on the natural monomer equivalents of the selected sequence.

HELM Auto-pair tool

Complementary strands of oligonucleotides can now be selected and automatically paired in the new ChemDraw editor. When paired, hydrogen bonds will be placed between the strands according to Watson-Crick base pairing, with maximum overlap in complementarity between the strands. For sequences containing custom monomers, the hydrogen bonding will be placed according to Watson-Crick base pairings based on the natural monomer analogs. The auto-pair tool will appear on the right-hand context toolbar when two oligonucleotide sequences are selected.

Show 3' and 5' ends of oligonucleotides

A new option has been added to the Biopolymer section of the Properties panel in the new ChemDraw editor which allows users to display the 3' and 5' ends of an oligonucleotide on the canvas. When an oligonucleotide is selected, users can choose to show or hide the label by selecting or unselecting this option.

Chemical Symbols

Common symbols used in chemical names and reaction conditions can now be added to a ChemDraw text element in the new ChemDraw editor using the new Chemical Symbols tool. This tool will be available on the right-hand context toolbar when editing in a text element on the ChemDraw canvas.

Join tool

A new join tool is now available on the right-hand context toolbar of the new ChemDraw editor. When used, the join tool allows users to combine structures on the ChemDraw canvas by merging two or more selected atoms into a single atom.


What’s New

The latest release of Signals introduces significant enhancements to the ChemDraw+ application.  We've improved the user drawing experience by incorporating new rotate tools into the interface. The HELM editing capabilities have been expanded, now featuring the ability to add sense & antisense annotations to sequences and draw hydrogen bonds between natural and non-natural nucleobases. Additionally, the HELM Monomer Curation application now has an improved editing experience with the integration of a new ChemDraw editor.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

-    Sharing Drawings
-    Rotate 180 degrees vertically and horizontally
-    Complementary strands inserted to canvas in a single line with no line wraps
-    Atom-mapped SMILES now supported in HELM strings for copy/paste
-    Sense & antisense annotations now available on oligonucleotide biopolymers
-    Drawing hydrogen bonds between complementary strands with non-natural nucleobases
 

HELM Monomer Curation 

-    New ChemDraw editor available in ‘New Monomer’ form
 

ChemDraw+

Sharing Drawings

Users with sharing privileges can now share drawings in ChemDraw+ with other users or groups. This can be done either from an open drawing in the web editor view or from the actions menu in the Drawings, Favorites, or Notebook detailed list views within the application.

Read, Write or Full access control can be specified during the sharing process. Once shared, access can be removed or modified as needed.  

Rotate 180 degrees vertically and horizontally

New rotate tools are available in the right-side context based toolbar in the new editor. When used, these allow 180-degree rotation both horizontally and vertically, preserving molecular stereochemistry. This differs from flip tools, which mirror stereochemistry within a structure when used.

Complementary strands inserted to canvas in a single line with no line wraps

Complementary strands of any sequence length are now inserted onto the ChemDraw canvas from the HELM Text tab in a single horizontal line without line wrapping. The strands are aligned based on the complementarity of the base pairing. 

Atom-mapped SMILES now supported in HELM strings for copy/paste

Atom-mapped SMILES are now supported in ChemDraw when inserting HELM strings or pasting them to the canvas. Additionally, when generating a HELM string for a sequence that includes an unknown or in-line monomer, the resulting HELM string will now use atom-mapped SMILES. This replaces the previously used extended SMILES format.

Sense & antisense annotations now available on oligonucleotide biopolymers

A new biopolymer section has been added to the Properties panel which will allow the addition of sense & antisense annotations to an oligonucleotide in the new ChemDraw editor. When an annotation is applied, a label will be added to the oligonucleotide on the canvas. The annotation will also be included in the generated HELM string for that biopolymer.

Drawing hydrogen bonds between complementary strands with non-natural nucleobases

Chemists can now manually draw hydrogen bonds between complimentary strands of DNA/RNA that are generated in ChemDraw containing non-natural nucleobases. The hydrogen bonding tool can be selected and used to place the appropriate hydrogen bonds according to Watson-Crick base pairing of the natural nucleobase analog.

HELM Monomer Curation

New ChemDraw Editor available in New Monomer form

A new ChemDraw editor is now available in the New Monomer form of the HELM Monomer Curation application. The new drawing experience provides a redesigned interface with a dynamic toolbar that adapts to the space available. As tools collapse to fit the view, they remain easily accessible through menus on the toolbar. The new editor offers additional tools to enhance the drawing experience, including panning, expanded zoom controls, rotate tools, and template tools.

Additionally, new collapsible and resizable ‘Properties’, ‘Query’ and ‘Guided Stereo’ panels are available on the right side of the editing canvas.