What’s New
We are delighted to release Signals BioDesign 26.7. This release makes Gibson Assembly cloning available to all systems and includes the ability to create sequences from all cloning outputs. We have also fixed a number of smaller bugs to improve overall product quality.
The following generally available improvements are available to users, administrators, and developers on the Signals platform. Some features may require appropriate licensing and/or administrator enablement.
- Cloning
- Gibson Assembly combinatorial assembly available to all systems
- Promotion of cloning outputs to sequences
Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.
Further Details
This section provides additional details about generally available improvements and beta capabilities included in Signals BioDesign 26.7. Some features may require appropriate licensing and/or administrator enablement.
Cloning
Previously available as a beta release, administrators can now configure templates that allow users to design combinatorial assemblies using the Gibson Assembly cloning method. A dedicated settings section in Signals Configuration allows administrators to manage and customize Gibson Assembly configurations for their users.
Users can design up to 1,000 molecular constructs using the Gibson Assembly method. Because the assembly is combinatorial, every sequence in Bin 1 is combined with all sequences in subsequent bins. The planner previews the total number of constructs that will be generated by the plan. For longer-running processes, users can optionally receive in-app and email notifications. When the run is complete, the Gibson Assembly provides outputs for Constructs, Fragments, and Primers. Users can inspect any warnings or errors that occur during the assembly process.
Once the user is happy with the Gibson Assembly outputs, they may choose to take a variety of actions on them. This includes downloading output or promoting them as BioDesign Sequences. Once promoted to a BioDesign sequence, any user with access to that DNA collection can access the newly created sequences. Note that creating Gibson Assembly cloning outputs is not subject to any admin defined duplicate check rules, but promotion to sequences adheres to settings on uniqueness set by the administrators.
