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What's New

Explore recent and historical product updates for Revvity Signals' Cloud Native SaaS Software 

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What's New

We are delighted to release our new version of Signals, 25.10. This release brings enhancements in versioning, equations, Variation Tables, Inventory and Synergy amongst others. We have new beta capabilities for viewing published data from Material libraries and around calculating protein properties. We have extended beta capabilities around Hierarchical Tables and Contextual Lists. The beta capabilities around text extraction from images and publishing samples are now available to all systems. Finally, we have also fixed a number of small bugs.

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator. 

  • Fundamentals
    – Origin Template (Original Name) property for versioning 
    – Increase of Task creation limit to 2000
  • AI
    –Text Extraction from Images for Signals One customers available to all systems*
    –Admin options to enable/disable AI functionality in Signals One available to all systems*
  • Data Workflows & Analytics*
    –SPR Data Import App available in Spotfire for Signals now supports Carterra file schema versions up to 10
  • SAR & Decisioning*
    –View Published Data from Material Library (beta)
  • Synergy†
    –Failed Status on Work Orders
    –Choice of Work Order transition when submit the only Synergy Experiment
  • Chemistry
    –Inclusion of Barcode to Internal Enumerator mapping
    –Inventory Decrements from Parallel Experiments
    –Context-sensitive ChemDraw floating toolbar
    –Drag-and-drop RXN files onto the ChemDraw canvas converts to CDXML
    –Atom numbers can now be enabled via a checkbox in the Properties panel
  • Admin Defined Tables, Variation Tables and Hierarchical Tables
    –Calculate Number with Unit from a Number property
    –Calculate Maximum
    –Publish Samples available to all systems
    –Updates to the Internal Reference Column Name Configuration
    –Addition of Internal Reference Lookup in Variation Table
    –Copy/Paste with Hidden Rows in a Variant Table
    –Internal Reference type properties can be used as source for Contextual Lists (beta)*
    –Search of Hierarchical Tables (beta)*
    –Hierarchical table data optionally included in exported PDF (beta)*
  • Inventory
    –Updates to Bulk Container Import
    –Return Containers to Home Location
    –Updates to Container Aliquot Workflow
    –Create Sublocations from Parent Location
    –Deleted Locations removed from Recent Locations
  • Materials
    –Loading Measure Added to Number with Unit in Materials
    –Update to Batch/Lot page
    –Calculated properties for protein complexes (beta)
  • ELN Archive
    –Preview ELN Archived Experiment Types directly in search results
  • Administration –Update Definition privilege
    –Spotfire for Signals Custom Apps Configuration available for Private Cloud now tracks Custom App module version*
    –Configuration Transfer of Contextual Lists in Worksheets (beta)
    –Configuration Transfer of Hierarchical Table Templates (beta)
    –Hierarchical Tables included in Configuration Report (beta)
    –Contextual Lists included in Configuration Report (beta)
  • Integrations & APIs
    –New API for exporting Orders
    –New APIs to support Supplier List
    –Enhanced APIs to support Supplier List Fields
    –Enhanced API for Text element export
    –New API to replace Chemical Drawing with a Duplex
    –Enhanced API to allow expanded chemical formats for uniqueness checking
    –New API to update Synergy Experiment Status
    –New API to close Synergy Work Orders
    –Enhanced API to allow creation of Work Orders with templates

* Requires Signals One license
† Requires Signals Synergy license
 

We also fixed several small bugs in this release. Details of the enhancements are described below.

Administrators should be aware that the Normalized Compound Salt Stripping tool will change to better handle fractional coefficients by altering how multi-fragment salts are interpreted from the Salt List. This change will occur in a future release and only apply to registrations subsequent to the change, existing compounds will remain with the prior understanding until edited.

Developers should note that this release addresses an issue with the GET /entities/{eid}/export endpoint, where the response returned an incorrect Content-Type header for Text entities. The header was set to text/plain, while the actual content is text/html. This only applies to text elements created through text file upload.

Data Factory administrators should be aware of several important updates. The latest version of Data Factory has officially exited beta, and all older versions of Data Factory projects and apps are now designated as “Legacy.” As part of this transition, it is no longer possible to create new legacy Data Factory projects through the user interface. We strongly encourage administrators to begin adopting the latest Data Factory features, as legacy projects will be fully deprecated in a future release. A simple migration path will be provided in a future release to support this transition.

Data Factory administrators should also note that the Advanced Security policies in Inventa apply an “AND” logic across all user groups, restricting access if any groups lack permissions. This behavior differs from the standard Signals security model and will be fixed to align with the standard in a future release.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in March 2026.

Further Details 

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

Fundamentals

A new property, called “Origin Template (Original Name)” is now captured on templated content such as ADTs, Variation Tables, Hierarchical tables, Worksheets and Experiments. This searchable property captures the name of the template used to create the item. Unlike the existing Origin Template property, which updates to reflect the current name of the Template will show the name at the time of creation. For items where the definition can be updated, the captured value will be updated if you update the definition. This allows the name of the template to be used to indicate and update the version of the definition. Note that this property is only present for content added or updated after this change.

Users will now be able to create up to 2000 tasks at a time through the task creation modal and via bulk actions. It should be noted the behavior of task creation is unchanged only the limit has been extended.

AI

For tenants with a Signals One license, users will now be able to utilize AI to extract and search by text from Images uploaded to Signals Notebook. This includes files of JPEG, PNG, and TIFF. This will apply to newly uploaded images only. Should a use load an image similar to the one below they would be able to search for it using keywords from the image like Control, Norovirus, etc.

Administrators will now be able to enable or disable new AI features utilizing the AI settings options. AI features still require a Signals One license and infrastructure to function. This just allows the admin more granular control on when these features are made available to end users. This currently only includes Text Extraction from Images for all systems

Data Workflows & Analytics

SPR Data Import App available in Spotfire for Signals now supports Carterra file schema versions up to 10.

Synergy

Sometimes a CRO is unable to successfully complete a Work Order for the Sponsor. For example, synthesis of a Design may fail, even after several successful steps or attempts, each submitted as a Synergy Experiment. Thus, at the time of Work Order submission, the CRO can alternatively submit a Work Order as Failed and provide a reason. The new Failed status is represented on the Work Order Kanban Board and included as an available External Notification.

Previously, in the case where there was only 1 Synergy Experiment for a Work Order, submitting the Synergy Experiment automatically submitted the Work Order. We now allow the user to choose how to transition the Work Order when submitting the 1 Synergy Experiment. The user can Submit the Work Order along with the Synergy Experiment, Fail the Work Order as they submit the Synergy Experiment, or do nothing to the Work Order (e.g., desire to continue adding more Synergy Experiments to the Work Order).

Chemistry

The barcode can now be mapped as part of importing SDFs into the Parallel Experiment internal enumerator along with the container ID. These values should also be visible in the stoich grids for the enumerated subexperiments.

We are now able to support Inventory Decrements from Parallel Experiments. Users may need to unhide the Inventory Decrement, Container ID and Barcode in the table:

Add New Compounds:

Containers will automatically update from Available to In Use and the Current User will update from Unassigned to the logged in user.

Scan or type the barcode into the search bar:

Add the container to the enumeration:

The container ID and Barcode will appear in the table. Users need to type in the full amount they will be removing from the container in the Inventory Decrements. This means that the user needs to know how much they will need for each sub experiment and put the total of that in the Inventory Decrement. This saves the user from having to navigate to every sub experiment to put in the Inventory Decrement:

Once the user types a value in the Inventory Decrement, the Current User, the Status and the Amount Available will be automatically updated. Users need to type in the Inventory Decrement before they enumerate the reaction:

Once the reaction has been enumerated, the Inventory Decrement column can no longer be updated:

Each sub experiment will show the Container ID and the Barcode, but not the Inventory Decrement column. This is done on purpose, so that users do not try to update the Inventory Container from a Sub experiment:

The ChemDraw editor now includes a context-sensitive floating toolbar. When content is selected on the ChemDraw canvas, a toolbar appears above the selection, displaying commonly used tools based on the selected object. As the pointer moves away from the toolbar, it automatically hides to minimize disruption to the editing process.

RXN files can now be dragged and dropped onto a ChemDraw canvas and converted automatically to cdxml for continued editing.

Atom numbers in ChemDraw can now be enabled for a selected object by selecting 'Show atom numbers' in the Atom section of the Properties panel

Admin Defined Tables, Variation Tables and Hierarchical Tables

Configuration Administrators can now define an equation to convert Numbers to Number with Unit properties. The CONVERTNUMBER function can be applied to properties of type Number with Unit. The function follows the format CONVERTNUMBER(Arg1, Arg2, Arg3) where Arg1 is an input property of type Number, Arg2 is the unit within the measure to apply to the Number. Arg3 optionally allows conversion to a different unit within the Measure.

A Configuration Administrator can also define equations to calculate the maximum of a series of data. The functions MAX and MAXOVER allow the selection of the largest of a set of data. If applied in a Header, the conditional maximum can be calculated using MAXOVER or by nesting an IF functions within MAX.

Publish Samples is now available to all systems. We’ve made an update to the Internal Reference Column Name drop down. When using the Internal Reference in configuration, the ability to refence the Internal Reference is not available for fields set to Multi-select. This has been updated to prevent misconfigurations.

If Multi-select is checked the Internal Reference is no long available to select in the Internal Reference Column Name:

Variation tables with hidden rows in the variant can be copy/pasted into. The hidden rows will be skipped over and the values will be added to the next row that is visible:

We’ve added a new Type in the configuration of the Variation Table. This is called Internal Reference Lookup. The purpose of this type is so that the administrator can configure a multi-select (from Materials already referenced in the experiment) that will put the materials into separate rows in the Variation Table.

Administrators should select the new Internal Reference Lookup from the Type drop down menu. Only 1 Internal Reference Lookup column is allowed per table so that the magnifying glass icon is associated with only one Internal Reference Lookup column. Administrator will need to select the “Limit Materials to same containing entity…” The “Show Lookup Icon…” will be automatically selected and greyed out:

When users make a new table in the experiment, they will see the magnifying glass in the top right corner of the table:

When users select the magnifying glass, they will see a list of Materials that are already referenced in the experiment. They can multi select all the Materials they would like to add to the Variation Table:

Selected Materials will be added in separate rows in the Variation Table:

Under the Property Type column Administrators can now choose Sample Properties as an option to be printed on the container labels:

We’ve made an update to the Bulk Container Import to have separate columns for the Material Library/Sample Type and the Material ID (Asset + Batch/Lot). This means that the example files have been updated and any template files that were used previously to bulk import containers, will need to be updated to have the additional column to import the data correctly:

Users can now return a series of containers to their Home Locations. Users can Search or filter for the containers that they would like to have returned to their Home Location on the Containers Search Table:

Once the containers are selected, and the Return to Home Location has been selected the containers with Home Locations will be updated. Any containers with out a Home Location will remain in the Current Location and they will be shown in the report as failures:

You can now split a container into multiple sub-containers with an option to make all aliquot amounts identical. This helps save time and reduce manual entry when preparing multiple identical vials.

Admins can now create a new sublocation directly while viewing a specific location. The parent location is automatically pre-filled in the creation form, making it faster and easier to build hierarchical location structures.

When a user selects a deleted location from the Recent options list, the system now displays a warning: “Location entry could have been trashed or may not exist. Please select a different location.”

After this warning the trashed location is removed from the Recent options list and cannot be reselected. If the user navigates away and returns, the deleted location will not reappear in Recent options. All workflows involving location selection will automatically exclude deleted locations going forward.

Materials

Admins can now utilize the measure Loading (mmol/g) for Number w/ Unit properties in Material Libraries and utilized in Sample mapping.

The Inventory Container Amount column has been moved to be next to Location:

ELN Archive

Support for previewing ELN Archived Experiment Types across all search result views

Administration

Administrators can now define if user can update the definition of tables and Worksheets. The Author privilege “Update Definition” will determine if the Update Definition option is available to users.

Signals One Private Cloud environments with Spotfire for Signals Custom Apps enabled now track module version of Custom Apps.

Integrations & APIs

We have added new APIs for exporting your Orders to a CSV or SDF file. The default value will be CSV. This is an asynchronous API flow with three endpoints to support it. First to initiate the bulk export, this requires a request body specifying the Orders you want to export and the columns you want to export. Second is to check the status of the export job. Third is to download the exported file.

We have added new APIs to fetch and update the Suppliers list. The update requires a well formatted CSV as part of the request. For convenience an example CSV is available via API.

We have enhanced APIs for stoichiometry tables, materials (assets and batches), and containers to support Supplier list field types. You will be required to specify the supplier list by the supplier ID as fetched in the new APIs. Alternatively, the Name and Country of the supplier may be used instead. Below are examples for Assets, Stoichiometry tables, and Containers using the supplier ID.

We have enhanced the entity export API to allow for Text entities to be exported as text files. This is specified using the “format” URL parameter which defaults to HTML if not specified for a text element.

We have added a new API to replace an existing chemical drawing with a paired duplex. The request body must contain two Chemical Drawing entities to be paired.

We have enhanced the API for uniqueness checking of a material to allow for additional chemical structures to be used. The content type must be specified as part of the value object for Chemical Drawing fields. InChI, SMILES, and HELM are now supported in addition to CDXML.

We have added a new API to support updating the Status of a Synergy Experiment. Synergy experiments can be updated from Active to Submitted, Submitted to Closed, Submitted to Active, and from Closed to Submitted based on the “action’ specified in the request.

We have added an enhancement to our APIs to support closing of Work Orders. This is a new action, “approve_and_close” allowed when updating Work Orders via API and transitions a Work Order from Submitted to Closed.

We have enhanced the Work Order creation API to allow for specifying a template as part of the request. It should be noted that if the Work Order template includes a template for the Synergy Experiment associated with the Work Order it will not be automatically created. To achieve this, users should use the API to create the Synergy Experiment after successful creation of the Work Order.

Further Details 

The following capabilities are in beta and are available for users, administrators and developers on the Signals platform upon request. Please contact your account representative or our support team if you would like access to the following features.

SAR & Decisioning

Quickly access published data without leaving the Material Library. The new Published Data tab automatically retrieves results for the selected material, displaying aggregated values by measurement type in a summary table. Interactive tables allow users to drill down to specific measurement results.

Admin Defined Tables, Variation Tables and Hierarchical Tables

Contextual Picklists now allow the use of Internal Reference properties as the source, including IDs from Sample, Task and Material tables, and Internal Search Attribute Lists.

Search is now enabled for Hierarchical Tables. Hierarchical Table is available as an option under the Type query tool. Additionally Hierarchical Table properties are available as individual query facets.

The data from Hierarchical Tables can also now be included in the Exported PDF as an attached .csv file.

Materials

A new set of calculated properties for protein complexes is available upon request for Custom and Protein material types and in the preconfigured Antibodies library. Molecular weight, isoelectric point, extinction coefficient, and total length can now be computed for complexes comprised of multiple protein parts linked to via internal references.

Up to 20 individual protein parts can be specified per calculation.

Updates to any of the underlying protein parts are automatically checked for when viewing the complex material.

Administration

Contextual Lists and Hierarchical Tables are now supported in both the Configuration Transfer process in addition to the new Configuration Report.

What’s New

We’re excited to introduce new enhancements that improve accuracy, performance, and flexibility across Signals ChemDraw. This release focuses on property calculations, HELM handling, and extended Python support for ChemScript. Finally, we have also fixed a small number of bugs.

 

ChemDraw Desktop

  • Properties Calculations
  • HELM Improvements
  • Support of Python 3.13.x, 3.10.x & 3.9.x

ChemDraw Desktop

Properties Calculations

LogP and Molar Refractivity (MR) calculations are now powered by RDKit, delivering more accurate and consistent results in the Chemical Properties window.

Property calculations have also been optimized for efficiency: when editing large structures with the Chemical Properties window open, updates are now queued to minimize lag and ensure a smoother editing experience.

 

HELM Improvements

Biopolymer cleanup has been significantly. Sequences appended to complementary strands are now properly arranged, and pendant sequences are tidied for clarity.

Leading and trailing phosphates, when omitted from a sequence, are matched with natural phosphates in the complementary strand.

Sequence selection behavior has also been improved: double-click and triple-click actions now provide intuitive selection of monomers, sequences, and groups.

Finally, the menu option Edit > Copy As HELM (Natural Analog) has been renamed to Edit > Copy As FASTA for clarity.

Python Support

ChemScript now supports Python versions 3.13.x, 3.10.x, and 3.9.x, giving developers greater flexibility for integration and automation.

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. This release brings enhancements to the drawing experience including the introduction of a new context sensitive toolbar in the drawing editor, monomer searching in the HELM editor, and highlight coloring options. Additionally, import/export support has been expanded. Finally, we have also fixed a small number of bugs.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

 

ChemDraw+

  • New context-sensitive ChemDraw floating toolbar
  • RXN file support in the ChemDraw editor
  • Turn on atom numbers for chemical objects
  • HELM editor now supports monomer structure searching
  • Highlight coloring now available
  • Notebook descriptions are now viewable in the application
  • Import & Export options have expanded

ChemDraw+

New context-sensitive ChemDraw floating toolbar
 

A context-sensitive floating toolbar is now available in the ChemDraw editor. When objects are selected on the ChemDraw canvas, a toolbar appears above the selection, displaying commonly used tools based on the selected object. As the pointer moves away from the toolbar, it automatically hides to minimize disruption to the editing process.

 

RXN file support in the ChemDraw editor

RXN files can now be dragged and dropped onto a ChemDraw canvas and converted automatically to cdxml for continued editing.
 

Turn on atom numbers for chemical objects

Atom numbers in ChemDraw can now be enabled for a selected object by selecting 'Show atom numbers' in the Atom section of the Properties panel.
 

HELM editor now supports monomer structure searching

The HELM editor now supports structure-based monomer search alongside text search, using a new Structure button and preview panel in the Peptide, RNA/DNA, and Chem/Blob tabs. Structures can be pasted from common formats (cdxml, cdx, SMILES, molV2000/3000, InChI) and searched as substructure, similar, full, exact, or full including tautomers, with results returned directly in the monomer panel. Structure and text filters can be combined to refine monomer results within the active library.

 

Highlight coloring is now available

You can now highlight atoms, labels, and bonds to draw attention to specific parts of a chemical structure to facilitate clear communication and focused presentations. This feature is available in the Colors section of the Properties panel or as a tool in the right-hand context toolbar. Choose a highlight color from the predefined palette or enter an exact hex code to create publication-ready chemical drawings.

Notebook descriptions are now viewable in the application

Notebook descriptions are now displayed in ChemDraw+ in both the Notebook List and Notebook Details views.

Import & Export options have expanded

ChemDraw+ now supports importing MOL and RXN files. When these files are brought into the application, they are automatically converted to CDXML format, enabling full editing capabilities within ChemDraw+. Additionally, export options in ChemDraw+ have expanded to include expanded MOL and SD files (V3000) as well as RXN files. 
 

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. This release enhances the drawing and analysis experience with LogP calculation in the ChemDraw analysis panel, new support for generating hairpins, and streamlined notebook workflows in ChemDraw+. Additionally, support has been added for SD/RD files in the application. Finally, we have also fixed a small number of bugs.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

 

ChemDraw+

  • Add drawing to a notebook from its detail page
  • Copy drawings into a notebook
  • Rename notebooks directly from the breadcrumb
  • Import now supports SD and RD files
  • Calculate LogP in the Analysis panel
  • Generate hairpins from a single oligonucleotide
  • Drag-and-drop SD/RD files onto the ChemDraw canvas

ChemDraw+

Add drawing to a notebook from its detail page

Create and add a new drawing to a Notebook directly from the Notebook detail page in ChemDraw+. The drawing is created using the most recently used style sheet and given an automatic name, which can be updated from the breadcrumb.

Copy drawings into a notebook

Drawings can now be copied into a Notebook in ChemDraw+ from the drawing view and added to any selected Notebook in the application

Rename notebooks directly from the breadcrumb

Notebooks can be renamed directly from the breadcrumb whenever needed. Renaming is available for any Notebook that is not automatically named when created.

Import now supports SD and RD files

ChemDraw+ now supports importing SD and RD files. When these files are brought into the application, they are automatically converted to CDXML format, enabling full editing capabilities within the application.

Calculate LogP in the Analysis panel

LogP is now available as a calculated property in the analysis panel of the ChemDraw editor. The calculation is based on the current selection and supports structures containing fewer than 1,000 atoms or 150 heavy atoms.

Generate hairpins from a single oligonucleotide

The ‘auto-pair’ tool in the ChemDraw editor can now generate hairpins from a single oligonucleotide sequence. It identifies the region of maximum complementarity within the strand, places hydrogen bonds between complementary nucleobases, and forms a hairpin loop from the remaining unpaired nucleobases.

Drag-and-drop SD/RD files onto the ChemDraw canvas

SD and RD files can now be dragged and dropped onto a ChemDraw canvas and converted automatically to cdxml for continued editing.

What's New

We are delighted to release our new version of Signals, 26.1. This release brings enhancements in Tasks, Materials, Data Analytics, Inventory and Tables amongst others. We have new beta capabilities around Ontologies, inherited Material properties and improving the display of tables. The beta capabilities around Contextual Lists are now available to all systems. Finally, we have also fixed a number of small bugs.

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator. 

  • Fundamentals
    – Ontologies integration allows terms to be used across experiments, materials, tables, and more (beta)
  • Data Workflows & Analytics*
    – Spotfire-based workflows now integrate the Publish Results to Data Factory app
    – Data Assembly download
  • SAR & Decisioning*
    – Bulk Delete published data via the Inventa Dashboard
  • Chemistry
    – HELM editor now supports monomer structure search
    – LogP calculation now available in the Analysis panel
    – Drag-and-drop of SD/RD files onto the ChemDraw canvas converts to CDXML
    – Generate hairpins from oligonucleotides using the auto-pair tool
    – Allowing for edits to the Material ID in the Stoich grid
    – Updates to Salt Stripping to allow for fractional salts
  • Tables
    – Contextual Lists available to all systems *
    – Internal Reference type properties can be used as source for Contextual Lists available to all systems *
    – Hidden columns in Tables can be temporarily unhidden
    – Calculate Minimum
    – Updated admin experience for Admin Defined Tables and Variation Tables (beta)
    – Conditional data entry for Number properties in Admin Defined Tables and Variation Tables (beta)
  • Worksheets
    – Contextual List property available to all systems *
  • Inventory
    – Display barcode on Location and Container cards in inventory
    – Allow admins to define autofill patterns for grid locations
    – Support bulk export of internal requests
  • Materials
    – Type in sequence registration in Materials Library
    – Lineage viewer Show/Hide Properties UI update
    – Inherited Properties for Materials (beta)
  • Tasks and Requests
    – Updates to the Task Modal to facilitate different modes of task creation
  • Administration
    – Configuration Transfer of Contextual Lists available to all systems
    – Configuration Transfer of Contextual Lists in Worksheets available to all systems
  • Integrations & APIs
    – New API to fetch Signals Version
    – New APIs to support Hierarchical Tables
    – Enhanced API to allow adding Assets to materials table
    – New CRO APIs for file attachment and chemical compliance
    – Enhanced APIs for bulk updating Containers

* Requires Signals One license
† Requires Signals Synergy license
 

We also fixed several small bugs in this release. Details of the enhancements are described below.

Administrators should be aware that the Normalized Compound Salt Stripping tool has now been updated to better handle fractional coefficients by altering how multi-fragment salts are interpreted from the Salt List. This change applies to registrations subsequent to this update, existing compounds will remain with the prior understanding until edited.

Data Factory Administrators should note that the syncing material library may now be changed after deleting any Data Factory projects.

Data Factory Administrators should note that legacy Data Factory projects will be fully deprecated in a future release. A straightforward migration path will be provided in an upcoming release to support this transition.

Data Factory administrators should be aware that the behavior of System Generated IDs will be updated in a future release. File-based publications will no longer support System Generated IDs.

Data Factory administrators should also note that the Advanced Security policies in Inventa apply an "AND" logic across all user groups, restricting access if any groups lack permissions. This behavior differs from the standard Signals security model and will be fixed to align with the standard in a future release.

Administrators should be aware that we will be retiring the CRAIS Checker capability from Signals Notebook and Signals One. This capability, which was only available via request, was built to allow integration specifically to the Patcore CRAIS Checker database. Such workflows have been superseded by the Chemical "External Checking" capability which can be used against any chemical compliance database. Any customers still using the CRAIS checker are encouraged to update their workflows to use this capability instead. We encourage any customers who require assistance with this transition to contact our support organization and/or engage with our Professional Services team. The CRAIS Checker capability will be retired by March 31st 2026.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in July 2026.

Further Details 

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

Data Workflows & Analytics

The new app allowing to publish analysis results, associated to mandatory Compound/Batches pairs, to Data Factory 2.0 is now integrated in the out of the box workflows.

The Data Assembly step of the In Vitro Analysis allows assembling the data from the instrument with multiple sources like plate format information and external lookup tables. It is now possible to download, with the click of a button, the full content of the resulting table.

SAR & Decisioning

Users can now bulk delete published data via the Inventa Dashboard. After uploading a file that contains a list of Unique Result IDs, users can choose “Bulk Delete” to permanently delete those records from Data Factory. Note: System Generated URIs must be disabled by an Administrator in order to use Bulk Delete.

Chemistry

The HELM editor now supports structure-based monomer search alongside text search, using a new 'Structure' button and preview panel in the Peptide, RNA/DNA, and Chem/Blob tabs. Structures can be pasted from common formats (cdxml, cdx, SMILES, molV2000/3000, InChI) and searched as substructure, similar, full, exact, or full including tautomers, with results returned directly in the monomer panel. Structure and text filters can be combined to refine monomer results within the active library.

LogP is now available as a calculated property in the analysis panel of the ChemDraw editor. The calculation is based on the current selection and supports structures containing fewer than 1,000 atoms or 150 heavy atoms.

SD and RD files can now be dragged and dropped onto a ChemDraw canvas and converted automatically to cdxml for continued editing. 

The ‘auto-pair’ tool in the ChemDraw editor can now generate hairpins from a single oligonucleotide sequence. It identifies the region of maximum complementarity within the strand, places hydrogen bonds between complementary nucleobases, and forms a hairpin loop from the remaining unpaired nucleobases.

Users will now be able to unlink the Material ID of chemicals added via the Quick Add. Unlinking the material does not erase the chemical from the drawing. It just removes the Material ID which previously could not be removed or altered.

In an update to the behavior of the Salt Stripper for Normalized Compounds, partial salts will now be fully stripped where previously only whole salt coefficients were recognized. This will not alter the batch level chemical name, MF, or mass values as those are calculated from the unaltered batch structure. This will just allow the salt table to more accurately reflect the stripped salts

Tables

Contextual Lists are now available to systems with a Signals One license.

End users can now temporarily display hidden columns in relevant Tables even if they do not have Edit on the content the Table is in. The Cog icon will now be shown and will display in blue if hidden columns contain data. The hidden columns can be exposed from this menu. The display of the columns is transient and the table will be returned to its original state upon a page refresh. This applies to all relevant tables including Admin Defined Tables, Variation Tables, Hierarchical Tables, Design Tables, Sample Tables and Material Tables.

A Configuration Administrator can also define equations to calculate the minimum of a series of data. The functions MIN and MINOVER allow the selection of the lowest number of a set of data. If applied in a Header, the conditional minimum can be calculated using MINOVER or by nesting an IF functions within MIN.

Worksheets

Contextual List properties into Worksheets is now available to all systems with a Signals One license.

Inventory

Barcodes are now visible on both the Location and Container Card as well as in the List view within Inventory. The display order of barcodes follows the property sequence defined in Location Type and Container Type settings.

Admin users can now define grid autofill behaviour by setting up pattern mappings for Location Types. Available options include User Selection, Left-to-Right Pattern or Top-to-Bottom Pattern. 

This enhancement ensures grid locations are populated according to the pattern selection configured in the Location Type settings.

Inventory users with Export Container permissions can now export Internal Requests in two formats, No Structure (CSV) or SDF.

This enhancement allows users to download and share data in the required structure for further processing or integration with other systems.

Materials

End users can now register sequence-based materials such as DNA, RNA, and Proteins and the pre-configured Plasmids library by copying in a sequence from their clipboard. A sequence string, FASTA, GenBank, and GenPept entries can be pasted in when registering materials in the smart folder.

The material lineage table Show/Hide Properties menu has been updated to more concisely display properties from various material libraries present in the viewer. Material library names now act as a header when scrolling through the list of selectable properties.

Tasks and Requests

The Task creation modal has been updated to more clearly indicate the number of tasks that will be created and allow for a single task to include all references from the Sample Bulk actions as seen below.

The Task creation modal driven from the “Add Content” menu has also been updated for greater parity to task creation from the Sample Table Bulk Actions.

Updates to the helper text at the modal to indicate the total number of tasks that will be created.

Administration

The support for Configuration Transfer of Contextual Lists is now available to all systems with a Signals One license.

Integrations & APIs

We have added a new API for querying your current Signals version.

We have added new APIs to support fetching and updating Hierarchical Tables. These APIs allow you to fetch, create, and update content of hierarchical tables.

We have enhanced our API to allow Assets to be added to the Materials Table without requiring a Batch/Lot. The request body will accept the Asset ID where previously it required a Batch ID.

We have added new APIs to bulk update Responsible Person, Amount, and Expiration Date for Containers. This will update the selected field for all Containers included in the request body. Only one of these fields can be bulk updated at a time for all Containers. 

The API is asynchronous and kicked off in three steps: Create the Bulk Update Field Job -> Check the Status of the Job -> Get a report of a completed Job as a CSV.

We have added new APIs to bulk return Containers to their Home Locations. This will return all the containers to their Home locations. Only containers with a Home location set will be returned.

The API is asynchronous and kicked off in three steps: Create the Return Home Job -> Check the Status of the Job -> Get a report of a completed Job as a CSV.

We have added new APIs specific to our Synergy Product CROs for attaching files and fetching/updating chemical compliance. These allow for specific APIs to be utilized by CRO users. This enables customers External Actions to read and write for CRO users without exposing details that CROs are restricted from seeing or interacting with.

Beta Features 

The following capabilities are in beta and are available for users, administrators and developers on the Signals platform upon request. Please contact your account representative or our support team if you would like access to the following features.

Fundamentals

Ontologies are now supported in Signals.  Administrators may connect to most public ontologies available on either the BioPortal or Ontology Lookup Service (OLS) providers.

After connecting to an External Ontology Source, Administrators can subset a specific Ontology into a new type of Attribute List called an Ontology List. 

Admins can incorporate Ontology Lists into most Templates within Signals where Attribute Lists are already supported, including Material Definitions, Experiment Templates, Table Templates, Worksheet Templates, Sample Properties, and more

When interacting with a field associated with an Ontology List, users can type-ahead to find a term directly (including matching based on synonym).  Alternatively, users can select the magnifying glass icon to browse the hierarchical ontology tree.

You can now split a container into multiple sub-containers with an option to make all aliquot amounts identical. This helps save time and reduce manual entry when preparing multiple identical vials.

When printing Experiments or other objects to PDF, ontology details can be optionally included, which will embed a CSV with ontology metadata, like Preferred Name and IRI.

Tables

The administrative experience for Admin Defined Tables and Variation Tables has been updated to match Hierarchical Tables. This updated design matches that previously released for Hierarchical tables and provides a smoother experience for defining and reordering properties within the table.

Included within the administrative update described above, we have also extended the configuration of Number properties in Admin Defined Tables and Variation Tables. Number properties can be defined with conditions for data entry, ranges can be set and the property set to either not allow an out of range value, or to provide a visual indication when a value does not match.

Materials

Administrators can now configure inherited properties in all material libraries. Data field values can now be passed down (i.e. inherited) from one material to another using internal reference links. Updates to the source data are automatically propagated to any inheriting entity and are kept in sync.

What's New

We are delighted to release our new version of Signals, 26.2. This release brings enhancements in Synergy, Chemistry, Materials, Inventor, SAR and Data Workflows amongst others. We have extended the grid view to the Chemical Reactions smartfolder, we have also provided a warning if users are using an outdated experiment template. We have new beta capabilities around Native Analytics and providing graphs in tables. The beta capabilities around Hierarchical tables, the Configuration Report, the updated admin experience for tables, and the View Published Data in Material libraries are now available to all systems. Finally, we have also fixed a number of small bugs.

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator. 

  • Fundamentals
    – Grid View in Chemical Reactions Smartfolder
    – Ontology integration now supported in Synergy, including Collaboration, Idea, Work Order, and Synergy Experiments Templates, as well as Designs and Reference Table fields (beta)
  • Data Workflows & Analytics*
    – Grid view for normalization and curve fitting results
    – Data Parser robust data type selection
    – Administrative access to Signals Native Analytics (beta)
    – Curve fitting extended to Logistic regression 3-4-5 Parameters models (beta)
  • SAR & Decisioning*
    – View Published Data from Material Library is now available to all systems
    – Overwrite Publications via the Publish Results to Data Factory app
    – HELM Matched Monomer Pairs ChemCharts data function
    – Extract GenBank Feature ChemCharts data function
  • Synergy†
    – Advanced Search for CRO users in the CRO application
    – Flexible selection of Synergy Experiment Templates by CRO users in a Work Order
    – Synergy Experiment properties can inherit from Work Order properties
    – Access to HELM Monomer Libraries can now be granted to CRO Departments
    – Append Template to Samples for CRO users
  • Chemistry
    – Predicted pKa calculation added to the ChemDraw Analysis panel
    – Hairpins can now be generated from oligonucleotides with pendant chemical and peptide attachments
    – Auto-pair tool preserves user defined hydrogen bonds when pairing complementary strands and hairpins
    – Auto-pair tool now supports pairing of selected oligonucleotide fragments
  • Tables
    – Hierarchical Tables available to all systems *
    – Total row limit for Hierarchical Tables available to all systems *
    – Header display settings for Hierarchical tables available to all systems *
    – Define Internal or External Data Sources in Hierarchical Tables available to all systems *
    – Add Inventory Columns to Hierarchical Tables available to all systems *
    – Internal Reference column limited to Materials in a Material table in the same containing entity setting available to Hierarchical tables available to all systems *
    – Search of Hierarchical Tables available to all systems *
    – Hierarchical table data optionally included in exported PDF available to all systems *
    – Updated admin experience for Admin Defined Tables and Variation Tables available to all systems
    – Conditional data entry for Number properties in Admin Defined Tables and Variation Tables available to all systems
    – Conditional data entry for Number with Unit properties in Admin Defined Tables and Variation Tables
    – All data in a table can be cleared upon copy
    – Define behavior of Headers in Admin Defined Tables and Variation Tables
    – Data sources in in Admin Defined Tables and Variation Tables can be deleted
    – Hierarchical Tables can be selected as the source for Contextual Lists *
    – Definition and display of Scatter Plots on Admin Defined Tables (beta) *
  • Inventory
    – Add Container Property Fields to Material Tables
    – Add Parent Container field to Containers Search Table
    – Copy path button next to location field
    – Enable Supplier List mapping from Reactants to Material properties with auto‑populate
  • Materials
    – Structure Preview for Materials Table
    – Type in sequence registration in materials table and bulk import
    – List and Attribute List fields in material IDs
  • Administration
    – Configuration Report available to all systems
    – Configuration Transfer of Hierarchical Table Templates available to all systems
    – Hierarchical Tables included in Configuration Report available to all systems
    – Contextual Lists included in Configuration Report available to all systems
    – Warning message displays when users clone experiments that are based on outdated system templates
  • Integrations & APIs
    – Selected rows in an Admin Defined Table can be identified in an External Action
    – Selected rows in a Variation Table can be identified in an External Action
    – Multiple Key:Value headers for Data Sources and Notifications
    – API to fetch Security Policy
    – API to add structures to Chemical Drawings with BILN

* Requires Signals One license
† Requires Signals Synergy license
 

We also fixed several small bugs in this release. Details of the enhancements are described below.

Administrators should be aware that we are planning to retire most of the In Vivo Apps from the Signals One App Store in Spotfire. Specifically the following Apps will no longer be available: Study Designer, Dose Preparation, Baseline Capture, Sequence Of Events, Sequence File Generator, Mass Spec, Dose Verification, Business Rules, and Data Model Designer. The PK Parameters App continue to be supported and will remain in the Signals App in Spotfire in Signals One. We encourage any customers who require assistance with this transition to contact our support organization and/or engage with our Professional Services team. This change is anticipated to happen in our next release, 26.3.

Administrators should be aware that we will be retiring the CRAIS Checker capability from Signals Notebook and Signals One. This capability, which was only available via request, was built to allow integration specifically to the Patcore CRAIS Checker database. Such workflows have been superseded by the Chemical "External Checking" capability which can be used against any chemical compliance database. Any customers still using the CRAIS checker are encouraged to update their workflows to use this capability instead. We encourage any customers who require assistance with this transition to contact our support organization and/or engage with our Professional Services team. The CRAIS Checker capability will be retired by March 31st 2026.

Data Factory administrators should note that the Publication Unique ID and Parent Publication Unique ID generation in the Publish Results to Data Factory app has been updated for robustness and now includes DateTime and the originating Experiment Name.

Data Factory administrators should be aware that the behavior of System Generated IDs has been updated. File-based publications no longer support System Generated IDs.

Data Factory Administrators should note that legacy Data Factory projects will be fully deprecated in a future release. A straightforward migration path will be provided in an upcoming release to support this transition.

Data Factory administrators should also note that the Advanced Security policies in Inventa apply an "AND" logic across all user groups, restricting access if any groups lack permissions. This behavior differs from the standard Signals security model and will be fixed to align with the standard in a future release.

Data Factory administrators should note that POST /api/v2/projects/{projectId}/results/{resultSchemaId}/rows is deprecated. Instead, supply a Unique Result ID and use PUT /api/v2/projects/{projectId}/results/{resultSchemaId}/rows/{rowId}

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in July 2026.

Further Details 

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

Fundamentals

The grid view is now available in the Chemical Reactions Smartfolder. As in other grid views, customers will be able to select the properties they want displayed and can sort or filter on properties by selecting the appropriate column header. It should be noted that export is not currently available in the chemical reactions grid view at this time but will become available in a future release.

Data Workflows & Analytics

In addition to the Card view, a Grid, or Table view is now available to review both Normalization and Curve Fitting results. This tabular presentation is not only more compact but also allows hiding or reordering any column (e.g. Signals to Background ratio or IC50) to rank the results.

In the case of the Normalization results, the plate heatmap or the histogram views are available, as shown above.

At the level of the configuration of Parser Definitions, when creating or modifying a Parser Definition, the type of data extracted from the instrument data file is either predefined (and grayed out) or can be selected from a consistent list of options.

SAR & Decisioning

Users may now access Published Data directly from a Material Library. The Published Data tab automatically retrieves results for the selected material, displaying aggregated values by measurement type in a summary table. Interactive tables allow users to drill down to specific measurement results. 

Users can now overwrite an existing publication when publishing results from a Spotfire workflow. In the Publish Results to Data Factory app, selecting Overwrite existing publication allows users to choose a prior publication, which is fully replaced with the new data. Standard users can overwrite only their own publications, while administrators can overwrite publications created by any user.

The latest ChemCharts introduces Matched Monomer Pair (MMP) Analysis for HELM sequences.  HELM MMP Analysis identifies pairs of aligned HELM sequences that differ by a single monomer and quantifies how the substitution impacts numeric properties.  The analysis also generates ranked predicted structures based on the learned MMP effects. 

The new ChemCharts Extract GenBank Feature data function enhances and replaces the now deprecated extract GenBank Regions data function.  Users can extract and split annotated regions from GenBank sequences.

Synergy

CRO users now have access to Advanced Search, including Chemical search, in the Synergy CRO application. CRO users access a dedicated search index with extra security measures, which excludes all hidden from CRO properties and ensures only entities from their CRO and Collaborations. 

When the Sponsor wants to give a CRO flexibility in how they report their data or when the work requested requires varying experimental formats, it may be easier to allow the CRO to select from a set of shared Synergy Experiments rather than specifying a single Synergy Experiment Draft. This is especially useful when requesting multiple assays in one Work Order. On a Work Order Template, an administrator can now choose between Require Synergy Experiment Draft or Allow CRO to choose from shared Templates. When the Work Order is configured to allow the CRO to choose, no Draft Synergy Experiment is required from the Sponsor and the CRO can select from a list of shared Synergy Experiment Templates when adding a Synergy Experiment. Note that Synergy Experiment Templates are shared on a per CRO Department basis in Synergy Configuration > Synergy Experiments > Templates. Finally, when a CRO user creates a Synergy Experiment from a Template, all Hidden from CRO field values must be provided on the Synergy Experiment Template or configured to inherit from the Collaboration or Work Order. 

Synergy Experiment Template attribute list fields can be configured to inherit the property value from the associated Work Order. (Fields can also inherit from the parent Collaboration.) If a field is set to inherit from Work Order, the field will automatically populate with the corresponding value from the associated Work Order. This value is populated either on the Draft Synergy Experiment or when the Synergy Experiment is created from a Template. All subsequent Synergy Experiments created by CRO users will also inherit that value. As a result, the Sponsor or CRO user does not have to repeatedly populate the same property, such as Project Code or Disease Target. Further, Hidden from CRO fields can be populated when a CRO is allowed to select their own Synergy Experiment Template.

Administrators with the privileges Administer Synergy, Manage CROs, and Manage Attributes can now grant CRO Departments access to specific HELM Monomer Libraries. In Synergy Configuration > CROs > Department Associations, administrators can associate one or more HELM Monomer Libraries with a CRO Department. Users in CRO Departments have access to a HELM Monomer Library if and only if they have an association with that library. (No additional configuration is required.) With library access, a user can access to the HELM monomer editor and search the library to add monomers to their chemical drawings. (Note: As always, all users, whether internal or CRO users, can hover to see the structure represented by a monomer notation added to an Experiment, Work Order (e.g., Designs), Synergy Experiment, etc. by another user, independent of their access to a HELM monomer library.)

Finally, the ability to Append Templates to Samples has been extended to CRO users in Synergy Experiments. 

Chemistry

Predicted pKa is now available as a calculated property in the ChemDraw editor Analysis panel. The calculation uses the current selection, supports structures with fewer than 100 heavy atoms, and returns the predicted pKa value, type (acid or base), and atom label. When atom numbering is enabled in the drawing, the corresponding atom number is also shown in the Analysis panel.

Hairpins can now be generated from oligonucleotide sequences that include pendant chemical linkers or peptides by using the auto-pair tool to automatically find base complementarity and place hydrogen bonds to form the hairpin structure.

When there are multiple ways to create a complementary strand or hairpin, the auto-pair tool can now be used after placing one or more hydrogen bonds between nucleobases. ChemDraw then uses those existing hydrogen bonds as a guide, preserves them, finds the best remaining base complementarity, and adds the hydrogen bonds needed to complete the complementary strand or hairpin.

The auto-pair tool now supports partial selections of oligonucleotide strands, pairing compatible nucleobases within the selected regions and adding the corresponding hydrogen bonds between them.

Tables

Hierarchical Tables are available to all systems.

The updates to the administrative experience recently released in beta is now available for all systems.

The update to allow Conditional Data Entry on properties of type Number is also available for all systems.

This capability has also been extended to allow Conditional Data Entry on properties of type Number with Unit in Admin Defined Tables and Variation Tables. Number with Unit properties can be defined with conditions for data entry, ranges can be set and the property set to either not allow an out of range value, or to provide a visual indication when a value does not match.

The administrator can now define that all of the data in an Admin Defined Table, Variation Table or Hierarchical Table is cleared when the table is copied. This setting supersedes any individual settings on the individual properties.

The administrative and end user experience for the definition and display of Headers in Admin Defined Tables and Variation Tables has also been updated to match Hierarchical tables. Headers are displayed in more consistent vertical array. The admin can define the maximum width of the header label, and the data entry fields, to allow optimal alignment. Admins can also define the maximum number of Headers in a vertical section, the Headers are arranged top down in a given section up to the maximum number upon which a new section is started. 

Data sources defined in Admin Defined Tables and Variation Tables can now be removed and replaced. The data source can be removed via the Data Sources panel.

Properties in Hierarchical Tables can now be used as a Source for Contextual Lists.

Inventory

Inventory Admins can now view and add container-specific properties directly in material tables for better experiment decisions and accurate inventory tracking.

The Containers Search Table now displays the Parent Container field, making it easier to identify aliquoted container relationships.

A copy button is now available next to the location path, allowing users to copy the full path as a single line.

Supplier List can now be mapped from Reactants to Material Properties, auto-filling the Material field in the Stoichiometry grid.

Materials

Admins are now able to add the Structure preview to the Materials Table by adding a new column of type “Preview” to the Materials table in the SN Config

For the end users, if the preview is available, they will be able to see the preview of the structure similar to what can be seen when they mouse of the information icon. If they do not have access to the material, they will not see the structure. Similarly, if a structure is not available, the preview will indicate that the structure isn’t available.

End users can now register sequence-based materials such as DNA, RNA, and Proteins and the pre-configured Plasmids library in a materials table and via bulk import by pasting in a sequence. A raw sequence string, FASTA, GenBank, and GenPept entries can be pasted in when registering materials in a materials table:

or by including raw sequence strings during a bulk import:

Administrators can now configure asset material IDs to include List and Attribute List field data when registering a material. Up to four configured fields can be included in the asset ID Sequence and will apply to newly registered materials.

Administration

Configuration Transfer for Hierarchical Tables is now available for all systems. The Configuration Report is also now available for all systems.

Warning message displays when users clone experiments that are based on outdated system templates. If an admin has updated a template and an end user clones an associated experiment or experiment-like object (i.e. parallel experiment, request, ADO, work order), a warning message explaining the copy is using an older template will trigger. The end user will have the option of proceeding with copying or creating a new experiment based on the updated template. 

Integrations & APIs

External Actions on Admin Defined Tables and Variation Tables can now be configured to send selected row IDs. If the action is configured with a POST action, the end user will be able to select individual rows in the table. The resulting call will then contain the individual row IDs in the body of the call.

We have added a new API for fetching a text copy of your tenants Security Policy. This API is only available to System Administrators.

We have added enhanced the API for adding Chemical Structures a chemical drawing to support BILN chemical format. The datatype “biln” and the biln string is passed as a in the request body.

We have enhanced External Notifications, External Data Sources, External Chemical Sources, and External List to allow multiple headers as part of configuration. Existing headers will not be impacted but will allow for additional headers to be added.

Beta Features 

The following capabilities are in beta and are available for users, administrators and developers on the Signals platform upon request. Please contact your account representative or our support team if you would like access to the following features.

Fundamentals

Ontology integration now supported in Synergy, including Collaboration, Idea, Work Order, and Synergy Experiments Templates, as well as Designs and Reference Table fields

Data Workflows & Analytics

Signals Configuration allows access to Analytics definitions.

Access to the Analytics definitions is restricted to System administrators and Users with the “Manage Analytics Definitions” privilege.

The first set of system Analytics definitions provided out of the box are 3-4-5 Parameter logistic curve fittings.

These definitions are currently read-only and can be used in the In Vitro Analysis object, when not disabled.

In an In Vitro Analysis, it is now possible to choose any of the 3, 4 or 5 Parameters logistic curve fittings:

Tables

Administrators can now define Scatter Plots that will be displayed in Admin Defined Tables. Administrators can choose if a Scatter Plot is displayed, choose the properties for the axes, the color and shapes and ranges for the axes. If the administrator has representative data they can view a plot via the Try It Out.

The Scatter plot then appears automatically for the end user once they add data. The end user view is only available to users with a Signals One license.

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. This release enhances the drawing and analysis experience with predicted pKa calculations now available in the ChemDraw analysis panel and expanded capabilities of the auto-pair tool for complementary strands and hairpins. Finally, we have also fixed a small number of bugs.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

 

ChemDraw+

  • Edit notebook descriptions from the breadcrumb
  • Calculate predicted pKa in the Analysis panel
  • Generate hairpins with pendant linkers or peptides
  • Preserve user-defined hydrogen bonds when auto-pairing
  • Auto-pair selected oligonucleotide fragments

ChemDraw+

Edit notebook descriptions directly from the breadcrumb

Notebook descriptions can now be edited directly from the breadcrumb whenever needed.

Calculate predicted pKa in the Analysis panel

Predicted pKa is now available as a calculated property in the ChemDraw Analysis panel. The calculation uses the current selection, supports structures with fewer than 100 heavy atoms, and returns the predicted pKa value, type (acid or base), and atom label. When atom numbering is enabled in the drawing, the corresponding atom number is also shown in the Analysis panel.

Generate hairpins with pendant linkers or peptides

Hairpins can now be generated from oligonucleotide sequences that include pendant chemical linkers or peptides by using the auto-pair tool to automatically find base complementarity and place hydrogen bonds to form the hairpin structure.

Preserve user-defined hydrogen bonds when auto-pairing 

When there are multiple ways to create a complementary strand or hairpin, the auto-pair tool can now be used after placing one or more hydrogen bonds between nucleobases. ChemDraw then uses those existing hydrogen bonds as a guide, preserves them, finds the best remaining base complementarity, and adds the hydrogen bonds needed to complete the complementary strand or hairpin.

Auto-pair selected oligonucleotide fragments

The auto-pair tool now supports partial selections of oligonucleotide strands, pairing compatible nucleobases within the selected regions and adding the corresponding hydrogen bonds between them.

What's New

We are delighted to release our new version of Signals, 26.3. This release brings enhancements in In Vitro Analysis, Synergy, Inventory, and Chemistry amongst others. We have extended beta capabilities around graphing in tables and curve fit definitions. The beta capabilities around calculated properties for protein complexes are now available to all systems. Finally, we have also fixed a number of small bugs.

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator. 

  • Fundamentals
    – The PDF export of experiments can be converted to local time in ISO 8601 format
  • Data Workflows & Analytics*
    – Personal Templates support in the In Vitro Analysis
    – Initial support for custom curve fit definitions and publication (beta)
  • Synergy†
    – Move Designs Table to different Idea
    – Move Design(s) to different Designs Table or Idea
    – Chemical Search for shared Chemical/Design Structures in Reference Tables for Sponsor and CRO
    – Reference Table property search for Sponsor and CRO
  • Chemistry
    – Support for pairing of multiple RNA/DNA strands to a single sequence
    – Structure searching for monomers in HELM Monomer Curation application
  • Tables
    – End user adjustment of Scatter Plots (beta) *
    – Export of image from Scatter Plots (beta) *
    – Highlight selected rows or points in the Scatter Plot and Table (beta) *
    – Conditional calculations can be contained within conditional calculations
    – Increase component limit from 30 to 50 in the Variation Table
  • Samples
    – Empty Sample tables in Templates
  • Inventory
    – Allow Multiple Additions of the Same Container in Materials Table and Stoichiometry Table
    – Add multiple (same) sublocations to a parent location easily
    – New Labels
  • InventoryGo ‡
    – Reconciliation and Rectification
    – Move
    – Consume
  • Materials
    – Calculated properties for protein complexes available to all systems
    – Inherited Properties for materials available to all systems
    – Log P, predicted pKa, and additional compound calculated properties
    – Configurable display units for calculated molecular weights
  • Search
    – New options for circular and linear Biological sequence searches
  • Administration
    – The 'created at' field in the system audit trail CSV export can be converted to local time in ISO 8601 format
    – Spotfire for Signals Custom Apps Configuration available for Private Cloud exports Spotfire for Signals Online Debug Logs *
  • Integrations & APIs
    – Selected rows in an Hierarchical Table can be identified in an External Action *
    – External Action for Edit Reviewers
    – API to create a Reference Table in a Work Order
    – API to add a reference(s) to a Reference Table
    – API for date based data extraction for SDF
    – Additional Chemical Structure formats for updating Materials
    – PKCE Support for Bearer Token Exchange

* Requires Signals One license
† Requires Signals Synergy license
‡ Requires InventoryGo license
 

We also fixed several small bugs in this release. Details of the enhancements are described below.

Administrators should be aware that we have retired most of the In Vivo Apps from the Signals One App Store in Spotfire. Specifically the following Apps are no longer available: Study Designer, Dose Preparation, Baseline Capture, Sequence Of Events, Sequence File Generator, Mass Spec, Dose Verification, Business Rules, and Data Model Designer. The PK Parameters App continues to be supported and will remain in the Signals App in Spotfire in Signals One.

Administrators should be aware that we will have retired the CRAIS Checker capability from Signals Notebook and Signals One. This capability, which was only available via request, was built to allow integration specifically to the Patcore CRAIS Checker database. Such workflows have been superseded by the Chemical "External Checking" capability which can be used against any chemical compliance database.

Data Factory Administrators should note that legacy Data Factory projects will be fully deprecated in a future release. A straightforward migration path will be provided in an upcoming release to support this transition.

Data Factory administrators should also note that the Advanced Security policies in Inventa apply an "AND" logic across all user groups, restricting access if any groups lack permissions. This behavior differs from the standard Signals security model and will be fixed to align with the standard in a future release.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in July 2026.

Further Details 

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

Fundamentals

The PDF export of experiments can be converted to local time in ISO 8601 format. When end users select the ‘Print to PDF’ option in an experiment, a new setting can be selected to “Use ISO 8601 local time” which will convert timestamps throughout the PDF to local military time with a UTC offset. 

Data Workflows & Analytics

In Signals One, In Vitro Analysis users can now save an instance of an In Vitro Analysis object as a personal Template:

Saved In Vitro Analysis personal Templates become then available for the user for subsequent new analysis.

Synergy

Given the new privilege to Move Designs, a Sponsor user can now move a Designs Table to a different Idea or move selected Design(s) to a different Designs Table. The user must have Full Control to an Idea in order to move Designs. 

As a Sponsor or CRO user, I can now search for my Work Orders based on the content of the Reference Table (e.g., list of Designs to be made or batches to be tested). Reference Tables allows the Sponsor to selectively share a sub-set of Design or Material Asset or Batch properties when requesting Design synthesis or assays to be run. If a Design Structure or Chemical Structure is included in the properties shared to the CRO, the Sponsor and CRO can use Chemical search to find the Work Orders containing a specific structure or sub-structure within Advanced Search or the Work Order Smart Folder. Note that the Chemical filter should be set to Parent to ensure that the Work Order containing the Reference Table is found. 

In addition, non-structure properties shared in the Reference Table can also be used when searching for Work Orders within Advanced Search or the Work Order Smart Folder.

Chemistry

ChemDraw now allows users to draw biopolymers with multiple complementary RNA strands for a single sense strand. When a set of hydrogen-bonded RNA sequences is created, ChemDraw detects the sense strand, identifies each first-degree complementary strand, and automatically places each complement beneath the sense strand according to hydrogen bond positions. The sense backbone is stretched as needed to minimize overlap, enabling side-by-side display of complements with proper alignment.

New capabilities have been added to the HELM Monomer Curation application for filtering and searching monomers based on chemical structures. Available as a button next to the text search field in the HELM Libraries list view, the ‘Structure…’ button opens a structure editor. 

After drawing a structure, users can select from substructure, similarity, full, and exact search options. Selecting ‘Search’ will then initiate the search filter. 

After completing a structure search, the ‘Structure…’ button transforms into an ‘Edit’ button. Selecting this button allows for previewing the structure, making changes to it, or removing it from the search filter. Structure searches can be combined with text-based searches to refine results even further.

Tables

Conditional calculations are now allowed to be used within other conditional calculations, such as within a CASE statement. For example a CASE statement can use another conditional statement such as an IF for each clause. A use case is to enact specific aggregate calculations over restricted values, such as if the sum of a given component in a formulation, such as water, is needed for an additional calculation.

The component limit in the Variation Table has been increased from 30 to 50, enabling more complex experimental designs and reducing the need to split large variations across multiple tables.

Samples

Admins will now be able to add an empty Sample Table to an Experiment or Experiment-like object template using the “Add Content” menu. Only one sample table is allowed in each template, once the sample table has been inserted it will be removed from the “Add Content” menu.

Admins should be able to then move the empty sample table to wherever in the template they would like to have the Sample table. Admins are also able to preselect the columns for the sample table in the template using the gear icon in the left corner.

For an end user, when creating the experiment, if there is an empty sample table in the template the empty sample table will appear in the experiment. When the user adds a sample, it will be added to the existing sample table with the selected columns as defined in the template. This will allow admins to vary which sample columns are shown from template to template without utilizing multiple sample templates.

If a user deletes all samples from the sample table, they will now need to delete the empty sample table with an additional click. The empty sample table can be included in the experiment copy function without including the samples.

Inventory

You can now add the same container multiple times in both the Materials and Stoichiometry tables. This enhancement improves procedure documentation clarity, stoichiometric accuracy, and inventory traceability, especially for workflows involving repeated dosing, split additions, or multi‑step reactions.

You can now quickly create multiple identical sublocations under a single parent location, making it easier to build and manage hierarchical location structures at scale while reducing repetitive setup effort.

New Label – 25 X 25 mm (3 slots, multiline) supports multiline with font size 6

New Label – 50 X 25 mm (3 slots) supports multiline with font size 8

New Label – 38 X 15 mm (QR Code)

New Label – 13 X 13 mm (QR Code)

InventoryGo

InventoryGo introduces mobile‑first inventory workflows that enable Reconciliation and Rectification, along with Move and Consume actions directly from the lab or storage location. Users can quickly reconcile physical inventory against system records, correct discrepancies, move containers between locations, and update consumed quantities through a streamlined, scan‑based experience—improving inventory accuracy, productivity, and audit readiness. InventoryGo is available as an add‑on capability. Please contact your Sales Associate for more information on enabling InventoryGo for your tenant.

Materials

Calculated properties for protein complexes for Custom and Protein material types and the preconfigured Antibodies library are now available to all systems. Molecular weight, isoelectric point, extinction coefficient, and total length can now be computed for complexes comprised of multiple protein parts linked to via internal references.

Inherited properties in all material libraries are now available in all systems. Data field values can now be passed down (i.e. inherited) from one material to another using internal reference links. Updates to the source data are automatically propagated to any inheriting entity and are kept in sync.

Log P, predicted pKa, and additional calculated properties are now available in Compound and Normalized Compound material types and the preconfigured Reagents (SNB) library. Administrators can selectively choose from a variety of physicochemical properties, drug-likeness and ADME predictors, structure and topology, ring system, atomic composition, and stereochemistry calculations.

Administrators now have the ability to choose different display units for calculated molecular weight properties in DNA, RNA, Protein, and Custom material types and the preconfigured Antibodies, Plasmids, and Primers libraries. Options include g/mol, kg/mol, dalton, and kDa.

Search

The Biological Sequence search now includes enhanced topology options to optimize your search results. The Linear option is for standard DNA and protein sequences, while the Circular option is ideal for plasmid searches where your target sequence may span across the junction between the end and start positions of the circular DNA molecule. 

Administration

Signals One Private Cloud environments with Spotfire for Signals Custom Apps enabled now allow the export of Spotfire for Signals Online Debug Logs.

The ‘Createdat’ and ‘modifiedat’ fields in the system audit trail CSV export can be converted to local time in ISO 8601 format. When admins export the system audit trail to CSV, they can adjust the format of timestamps by selecting the “Use ISO 8601 local time” option. This setting will convert the ‘createdAt’ and ‘modifiedat’ timestamps within the CSV to local military time with a UTC offset. 

Integrations & APIs

External Actions configured with a POST action on Hierarchical Tables will now include details of the selected rows and table layers within the body of the response.

We have added a new signing event external action trigger for “Edit Reviewers” this allows for maintaining any external actions used for initially adding reviewers to also be used if those reviewers are edited.

We have enhanced the API for patching material chemical drawings to accept additional chemical structure formats. The API now supports SMILES, InChI, and HELM chemical structures. You must specify the which in the request “Content-type” header. For the new content types the “filename” parameter will be ignored.

We have enhanced existing APIs to allow for creating Reference Tables in Synergy Work Orders. The library and entity type must be included in the request body. This will create a new reference table with no columns configured. Existing APIs for editing the displayed columns should be utilized to show columns.

We have added new APIs to add or delete reference(s) for existing Reference Tables. You must specify the action (create or delete) and the specific entities for the rows being added or deleted.

We have enhanced the search APIs for Signals Data Factory. You may now specify publication-from-date and publication-to-date as URL parameters in ISO 8601 format. This will filter results to the specified ranges.

We have added support for Proof Key for Code Exchange (PKCE) to our Bearer Token authorization flows. This is now an option for all current and future clients. This does not replace or break the Implicit Grant flow, it only adds the additional option. Additional details are available in the admin System Configuration Guide.

Beta Features 

The following capabilities are in beta and are available for users, administrators and developers on the Signals platform upon request. Please contact your account representative or our support team if you would like access to the following features.

Data Workflows & Analytics

Signals Configuration allows creation of custom Analytics definitions for Curve Fitting. A mathematical Expression Editor is now available in conjunction with the settings associated to the expression parameters, which can be locked to ensure consistent start values and limits.

Access to the custom Analytics definitions is restricted to System administrators and Users with the “Manage Analytics Definitions” permission. The multi-line editor checks the validity of the expression that can then be saved, enabled and shared for curve fitting (here an example of a bell-shaped expression).

The custom endpoints of a curve fit can be published for subsequent SAR & Decision Making. 

Tables

Configuration administrators can now give end users the ability to alter the configuration of Scatter Plots. The option to allow end users this ability is defined within the Visualization settings.

The end user can then access the setup of the chart to change the display of the axes etc. Changes are saved on demand if the user has Edit on the Experiment.

The end user can also decide to see the table and graph simultaneously. Selections in the table are highlighted in the graph view, and visa-versa. Users can select in the graph via dragging a rectangle or using a lasso to select an irregular area.

Users can also export an image of the graph, either to their clipboard, or as a downloaded file, or as an Image File directly back into the same experiment. Note that the exported image reflects the saved graph, unsaved changes by the end user will not be shown.

What's New

We are delighted to release our new version of Signals BioDesign, 26.3. This release brings enhancements to search and configuration transfer. Finally, we have also fixed a number of small bugs. 

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator. 

  • Search
    - New options for circular and linear Biological Sequence searches 
  • Administration
    - BioDesign settings are now available in Configuration Reports 

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

Further Details

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

Search

The Biological Sequence search now includes enhanced topology options to optimize your search results. The Linear option for standard DNA and protein sequences, while the Circular option is ideal for plasmid searches where your target sequence may span across the junction between the end and start positions of the circular DNA molecule.

Administration

Signals BioDesign is now included in Configuration Reports.

What's New

This latest Signals release includes updates to ChemDraw+, Signals Home Portal, and HELM Monomer Curation. Highlights include installer checksums in Signals Home Portal, structure search in HELM Monomer Curation, and accessibility improvements in ChemDraw+ that support WCAG 2.1 AA compliance. This release also includes bug fixes.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

Signals Home Portal

  • ChemDraw installer checksums are now available

ChemDraw+

  • Add/edit drawing descriptions from the breadcrumb
  • Pair multiple RNA/DNA strands to a single RNA/DNA sequence
  • Accessibility improvements towards WCAG 2.1 AA compliance

HELM Monomer Curation

  • Search for monomers by structure

Signals Home Portal

ChemDraw installer checksums are now available

Image 1 from Signals ChemDraw What's New 26.3_April 2026.docx

SHA256 checksums are now available from the ‘ChemDraw Installers’ tile in the Signals portal so users and IT teams can verify ChemDraw installers before deployment.

ChemDraw+

Add/Edit drawing descriptions directly from the breadcrumb

Drawing descriptions can now be added or edited directly from the breadcrumb whenever needed.

Pair multiple RNA/DNA strands to a single RNA/DNA sequence

ChemDraw now allows users to draw biopolymers with multiple complementary RNA strands for a single sense strand. When a set of hydrogen-bonded RNA sequences is created, ChemDraw detects the sense strand, identifies each first-degree complementary strand, and automatically places each complement beneath the sense strand according to hydrogen bond positions. The sense backbone is stretched as needed to minimize overlap, enabling side-by-side display of complements with proper alignment.

Accessibility improvements towards WCAG 2.1 AA compliance

ChemDraw+ now includes accessibility improvements that support WCAG 2.1 AA compliance and make the experience easier to use with keyboards, screen readers, and zoomed displays. The following improvements have been made:

 

    – Improved color contrast, focus states, and navigation cues
    – Expanded keyboard support across navigation, toolbars, and popovers
    – Enhanced screen reader support with better labels, headings, link text, and dialog names
    – Improved form accessibility, error messaging, and autocomplete behavior
    – Updated zoom, reflow, session timeout, and login page accessibility

 

HELM Monomer Curation

Image 4 from Signals ChemDraw What's New 26.3_April 2026.docx

New capabilities have been added to the HELM Monomer Curation application for filtering and searching monomers based on chemical structures. Available as a button next to the text search field in the HELM Libraries list view, the ‘Structure…’ button opens a structure editor.

Image 5 from Signals ChemDraw What's New 26.3_April 2026.docx

After drawing a structure, users can select from substructure, similarity, full, and exact search options. Selecting ‘Search’ will then initiate the search filter.

Image 6 from Signals ChemDraw What's New 26.3_April 2026.docx

After completing a structure search, the ‘Structure…’ button transforms into an ‘Edit’ button. Selecting this button allows for previewing the structure, making changes to it, or removing it from the search filter. Structure searches can be combined with text-based searches to refine results even further.